I don't really know what permits cross fertilisation, but I thought that the parents had to be fairly close in genetic terms. The two you have chosen are from different Series, and from what I remember about those DNA studies that have been done suggest that Mammillaria as we know it today might actually be polyphletic, which in practical terms means that those species might be really in different genera.
I know there are some intergeneric hybrids, such as Ferobergia, but although the appearance is quite different, in fact they are quite close genetically.
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Chris43, moderator